Combined treatment with enteric neural stem cells and chondroitinase ABC reduces spinal cord lesion pathology
نویسندگان
چکیده
منابع مشابه
P24: Neural Stem/Progenitor Cells Treatment for Spinal Cord Injury
لطفاً به چکیده انگلیسی مراجعه شود.
متن کاملChondroitinase ABC treatment and the phenotype of neural progenitor cells isolated from injured rat spinal cord.
The aim of the present study was to investigate whether enzyme chondroitinase ABC (ChABC) treatment influences the phenotype of neural progenitor cells (NPCs) derived from injured rat spinal cord. Adult as well as fetal spinal cords contain a pool of endogenous neural progenitors cells, which play a key role in the neuroregenerative processes following spinal cord injury (SCI) and hold particul...
متن کاملThermostabilized chondroitinase ABC Promotes Neuroprotection after Contusion Spinal Cord Injury
Background: Chondroitinase ABC (cABC), due to its loosening impact on the extracellular matrix scaffold, has been used to enhance regeneration of injured axonal tracts after spinal cord injury (SCI). However, cABC thermal instability at physiological temperature has limited its clinical application. The disaccharide trehalose has been shown to increase the stability of cABC in body temperature....
متن کاملP68: Combined Treatment of Spinal Cord Injury Using Transplantation of Motoneurons Derived Adipose Stem Cells and Adipose Mesenchymal Stem Cells Transfected with GDNF Following Valproic Acid Treatment
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متن کاملEffect of chondroitinase ABC on inflammatory and oxidative response following spinal cord injury
Objective(s): Chondroitinase ABC (cABC) treatment improves functional recovery following spinal cord injury (SCI) through degrading inhibitory molecules to axon growth. However, cABC involvement in other pathological processes contributing to SCI remains to be investigated. Here, we studied the effect of cABC I on oxidative stress and inflammation developed in a rat model of SCI.Materials and M...
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ژورنال
عنوان ژورنال: Stem Cell Research & Therapy
سال: 2021
ISSN: 1757-6512
DOI: 10.1186/s13287-020-02031-9